Hansa biopharma in its license collaboration with Sarepta Therapeutics to develop and promote imlifidase, an antibody-cleaving enzyme, for use as a pre-treatment to enable Sarepta’s AAV gene therapy to be administered for patients with Duchenne muscular dystrophy (DMD) and Limb-girdle muscular dystrophy (LGMD) who may otherwise not be eligible for treatment.
Under the terms of the agreement, Hansa will receive an upfront payment of $10 million and is eligible for additional development, regulatory and sales milestone payments potentially totaling up to $397.5 million. Hansa will book all sales of imlifidase and will earn tiered royalties up to the mid-teens on any incremental gene therapy sales that arise from treating antibody-positive patients enabled through imlifidase pre-treatment.